Necrólisis epidérmica tóxica en paciente infectado por virus de inmunodeficiencia humana

Abstract

Introduction: Toxic epidermal necrolysis is a multifactorial condition, with the participation, viral infections, drug interactions, and where the genetics plays an important role in susceptibility to adverse reactions. With the presentation of this article is to present the case report of a rare disease in the medical field, but which has a high rate of morbidity and mortality and sequelae. In patients with co-infection with human immunodeficiency virus increases 1000 the risk. We report a 32 year old male with a history of convulsive syndrome in management with phenobarbital and phenytoin, in coinfection human immunodeficiency virus recently diagnosed, no CD4 or viral load and antiretroviral unmanaged, introducing intake of ciprofloxacin 15 days before the start of the clinical picture is consistent with high fever, vesicular lesions Background Erythematosus, Confluent, showing anterior chest wall blebs of watery content, with detachment of the epidermis by exerting gentle pressure on the affected skin leaving Wet Areas Rojas, positive Nikolsky. Extension of the lesions which compromise 91% of her body, accompanied by pruritus of moderate intensity. During the hospital stay therapeutic management is performed with cyclosporine A, and immunoglobulin G specific human antibiotic and antifungal coverage with satisfactory evolution of the patient's hemodynamic status and skin lesions. [Escalante E, Oliva J, Paez E. Toxic epidermal necrolysis in a patients with HIV. Clinical case review. MedUNAB 2012; 15(1):68-72].