Central control of body temperature and its alterations: fever, hyperthermia and hypothermia
Abstract
Introduction. In mammals, controlling body temperature is vital. Consciousness and motor control in humans occur at a temperature of 37°C and any deviation can alter the cellular properties, generating physiological dysfunctions. In species such as rodents (their surface area/volume ratio facilitates heat loss) they maintain basal temperatures close to 30°C. This is different with animals such as pachyderms, whose temperature is lower compared to humans. This article aims to Identify the physiological aspects of thermoregulation. Topics. Descriptive literature review of articles published in different databases. Thermoregulation is the body's ability to establish and maintain its temperature, regulating heat production and loss to optimize the efficiency of metabolic processes. The main actor in this process is the central nervous system and its neuro-hormonal control on multiple levels. The thermal regulating center is located in the anterior hypothalamus. It receives information from the receptors of large vessels, abdominal viscera, spinal cord and the blood that perfuses the hypothalamus. When the core temperature increases, the thermoregulator activates efferent fibers of the autonomic nervous system, causing heat loss by convection and evaporation. When the temperature drops, the response is to decrease heat loss (vasoconstriction and less sweating); in addition, increase heat production by intensifying muscle activity. Conclusion. Thermoregulation is led by the hypothalamus, which regulates temperature increase and decrease by responding to the organism’s need to reach homeostasis and compensation, facing the alterations of the ambient temperature.
References
Flouris A, Schlader Z. Human behavioral thermoregulation during exercise in the heat. Scand J Med Sci Sports [Internet]. 2015 [citado 6 de feb. de 2020];25(S1):52–64. Recuperado a partir de: http://doi.wiley.com/10.1111/sms.12349
Morrison S. Central control of body temperature. F1000Research [Internet]. 2016. [citado 6 de feb. de 2020];5:1–10. Recuperado a partir de: http://f1000research.com/articles/5-880/v1.
López A. Actualidad en termorregulación. Pensar en Movimiento. Revista Ciencias del Ejercicio y la Salud [Internet]. 2014 [citado 6 de feb. de 2020];12(2):1–36. Recuperado a partir de: http://revistas.ucr.ac.cr/index.php/pem/article/view/14918
Cheshire W. Thermoregulatory disorders and illness related to heat and cold stress. Autonomic Neuroscience: Basic and Clinical. [Internet]. 2016 [citado 6 de feb. de 20];196:91–104. Recuperado a partir de: http://linkinghub.elsevier.com/retrieve/pii/S1566070216300017
Nakamura K. Central circuitries for body temperature regulation and fever. Am J Physiol Regul Comp Physiol [Internet]. 2011 [citado 6 de feb. de 2020];301(5):1207–28. Recuperado a partir de: http://ajpregu.physiology.org/cgi/doi/10.1152/ajpregu.00109.2011
Yang X, Ruan HB. Neuronal Control of Adaptive Thermogenesis. Front Endocrinol (Lausanne) [Internet]. 2015 [citado 6 de feb. de 2020];6(September):149. Recuperado a partir de: http://journal.frontiersin.org/Article/10.3389/fendo.2015.00149/abstract
Sund-Levander M, Grodzinsky E. Assessment of body temperature measurement options. Br J Nurs [Internet]. 2013 [citado 6 de feb. de 2020];22(16):942–50. Recuperado a partir de: http://www.magonlinelibrary.com/doi/abs/10.12968/bjon.2013.22.16.942
Flouris A. Functional architecture of behavioural thermoregulation. Eur J Appl Physiol [Internet]. 2011 [citado 6 de feb. de 2020];111(1):1–8. Recuperado a partir de: http://link.springer.com/10.1007/s00421-010-1602-8
Fernández E, Vilavella C, Saúl E, Sánchez E, Balmont G. Golpe de calor. FMC - Form Médica Contin en Atención Primaria [Internet]. 2016 [cited 2016 Nov 8];23(6):318–27. Recuperado a partir de: http://www.fmc.es/es/golpe-calor/articulo/90455666/
Gómez A. Trastornos de la temperatura corporal. Offarm [Internet]. [cited 2017 Jan 1];48–53. Recuperado a partir de: http://www.elsevier.es/es-revista-offarm-4-articulo-trastornos-temperatura-corporal-13108301
Maté M, Robles J, Boscá A, Aguado F. Trastornos de la regulación de la temperatura. Medynet [Internet]. 2007 [citado 6 de feb. de 2020];127(5):1–66. Recuperado a partir de: http://www.medynet.com/usuarios/jraguilar/Manual de urgencias y Emergencias/temp.pdf
Sessler D. The thermoregulation story. Anesthesiology [Internet]. 2013 [citado 6 de feb. de 2020];118(1):181–6. Recuperado a partir de: http://anesthesiology.pubs.asahq.org/Article.aspx?doi=10.1097/ALN.0b013e3182784df3
Hailes W, Cuddy J, Cochrane K, Ruby B. Thermoregulation During Extended Exercise in the Heat: Comparisons of Fluid Volume and Temperature. Wilderness Environ Med [Internet]. 2016 [citado 6 de feb. de 2020];27(3):386–92. Recuperado a partir de: http://linkinghub.elsevier.com/retrieve/pii/S1080603216301053
Camacho D. Estrés térmico en trabajadores expuestos al área de fundición en una empresa metalmecánica. Cienc Trab [Internet]. 2013 [citado 6 de feb. de 2020];15(46):31–4. Recuperado a partir de: www.cienciaytrabajo.cl
Parker G, Brotchie H. Gender differences in depression. Int Rev Psychiatry [Internet]. 2010 [citado 6 de feb. de 2020];22(5):429–36. Recuperado a partir de: http://www.ncbi.nlm.nih.gov/pubmed/21047157
“Revista Virtual Universidad Católica del Norte”. No.26, (febrero – mayo de 2009, Colombia), ISSN 0124-5821 - Indexada categoría C Publindex e incluida en Latindex
Tansey E, Johnson C. Recent advances in thermoregulation. Adv Physiol Educ [Internet]. 2015 [citado 6 de feb. de 2020];39(3):139–48. Recuperado a partir de: http://ajpadvan.physiology.org/lookup/doi/10.1152/advan.00126.2014
Walloe L. Arterio-venous anastomoses in the human skin and their role in temperature control. Temperature [Internet]. 2016 [citado 6 de feb. de 2020];3(1):92–103. Recuperado a partir de: http://www.ncbi.nlm.nih.gov/pubmed/27227081
Caron A, Richard D. Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis. Ann N Y Acad Sci [Internet]. 2016 [citado 6 de feb. de 2020];1–19. Available from: http://doi.wiley.com/10.1111/nyas.13263
Passlick-Deetjen J, Bedenbender-Stoll E. Why thermosensing, A primer on thermoregulation. Nephrol Dial Transplant [Internet]. 2005 [citado 6 de feb. de 2020];20(9):1784–9. Recuperado a partir de: http://ndt.oxfordjournals.org/cgi/doi/10.1093/ndt/gfh901
Hanna E, Tait P. Limitations to Thermoregulation and Acclimatization Challenge Human Adaptation to Global Warming. Int J Environ Res Public Health [Internet]. 2015 [citado 6 de feb. de 2020];12(7):8034–74. Recuperado a partir de: http://www.mdpi.com/1660-4601/12/7/8034/
Lin G, Scott J. Investigations of the constitutive overexpression of CYP6D1 in the permethrin resistant LPR strain of house fly (Musca domestica). Pestic Biochem Physiol [Internet]. 2011[citado 6 de feb. de 2020];100(2):130–4. Recuperado a partir de: http://linkinghub.elsevier.com/retrieve/pii/S0048357511000411
Benarroch E. Thermoregulation: Recent concepts and remaining questions. Neurology [Internet]. 2007 [citado 6 de feb. de 2020];69(12):1293–7. Recuperado a partir de: http://www.neurology.org/cgi/doi/10.1212/01.wnl.0000275537.71623.8e
Morf J, Schibler U. Body temperature cycles: Gatekeepers of circadian clocks. Cell Cycle [Internet]. 2013 [citado 6 de feb. de 2020];12(4):539–40. Recuperado a partir de: http://www.tandfonline.com/doi/abs/10.4161/cc.23670
Tupone D, Madden C, Morrison S. Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis. Front Neurosci [Internet]. 2014 [citado 6 de feb. de 2020];8(8 FEB):1–14. Available from: http://journal.frontiersin.org/article/10.3389/fnins.2014.00014/abstract
Lomniczi A, Wright H, Ojeda S. Epigenetic regulation of female puberty. Front Neuroendocrinol [Internet]. 2015 [citado 6 de feb. de 2020];36:90–107. Recuperado a partir de: http://linkinghub.elsevier.com/retrieve/pii/S0091302214000752
Nakamura K, Morrison S. Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. AJP Regul Integr Comp Physiol [Internet]. 2012 [citado 6 de feb. de 2020];292(1):R127–36. Recuperado a partir de: http://ajpregu.physiology.org/cgi/doi/10.1152/ajpregu.00427.2006
González-Alonso J. Human thermoregulation and the cardiovascular system. Exp Physiol [Internet]. 2012 [citado 6 de feb. de 2020];97(3):340–6. Recuperado a partir de: http://doi.wiley.com/10.1113/expphysiol.2011.058701
Saito T, Sadoshima J. Molecular Mechanisms of Mitochondrial Autophagy/Mitophagy in the Heart. Circ Res [Internet]. 2015 [citado 6 de feb. de 2020];116(8):1477–90. Recuperado a partir de: http://circres.ahajournals.org/cgi/doi/10.1161/CIRCRESAHA.116.303790
Nagashima K. Central Mechanisms for Thermoregulation in a Hot Environment. Ind Health [Internet]. 2006 [citado 6 de feb. de 2020];44(3):359–67. Recuperado a partir de: http://joi.jlc.jst.go.jp/JST.JSTAGE/indhealth/44.359?from=CrossRef
Wang H, Siemens J. Ion channels in thermosensation, thermoregulation and metabolism. Temperature [Internet]. 2015 [citado 6 de feb. de 2020];2(2):178–87. Recuperado a partir de: https://www.tandfonline.com/doi/full/10.1080/23328940.2015.1040604
World Health Organization (2019). Prevención y tratamiento de la hipotermia en niños con malnutrición grave. [online] Recuperado a partir de: https://www.who.int/elena/titles/bbc/hypothermia_sam/es/ [Accessed 16 Dec. 2019].
Ramos G, Grünberg G. Evaluation of the incidence trembling in the recovery room postanesthtic Avaliação. Anest Analg Reanim [Internet]. 2016 [citado 6 de feb. de 2020];29(1):2. Recuperado a partir de: http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-12732016000100002&lang=pt
Cordero A, Cordero I. Temblores posanestésicos. Rev Cuba Anestesiol y Reanim [Internet]. 2016 [citado 8 de febrero de 2020];15(3):243–8. Recuperado a partir de: http://scielo.sld.cu/pdf/scar/v15n3/scar08316.pdf
Brito V, Galvão C, dos-Santos C. Factors associated to the development of hypothermia in the intraoperative period. Rev Lat Am Enfermagem [Internet]. 2009 [citado 8 de febrero de 2020];17(2):228–33. Recuperado a partir de: http://www.ncbi.nlm.nih.gov/pubmed/19551277
Bissinger R, Annibale D. Thermoregulation in Very Low-Birth-Weight Infants During the Golden Hour. Adv Neonatal Care [Internet]. 2010 [citado 8 de febrero de 2020];10(5):230–8. Recuperado a partir de: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00149525-201010000-00004
Sultan P, David A, Fernando R, Ackland G. Inflammation and Epidural-Related Maternal Fever. Anesth Analg [Internet]. 2016 [citado 8 de febrero de 2020];122(5):1546–53. Recuperado a partir de: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00000539-201605000-00044
Corvetto A, Heider M, Cavallieri B. Hipertermia maligna: ¿cómo estar preparados? Rev Chil cirugía [Internet]. 2013 [citado 8 de febrero de 2020];65(3):279–84. Recuperado a partir de: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-40262013000300015&lng=en&nrm=iso&tlng=en
González G, Ulloa B. Hipertermia maligna: adelantándose a las complicaciones. Rev Otorrinolaringol y cirugía cabeza y cuello [Internet]. 2006 [citado 8 de febrero de 2020];66(1):51–4. Recuperado a partir de: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-48162006000100009&lng=en&nrm=iso&tlng=en
Wang L, Zou Z, Hou C, Liu X, et Al. Score risk model for predicting severe fever with thrombocytopenia syndrome mortality. BMC Infect Dis [Internet]. 2017 [citado 8 de febrero de 2020];17(1):42. Recuperado a partir de: http://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-2111-0
Hurtado V, Sendoya F. Implicaciones en la salud de los trabajadores originadas por la exposición térmica en cultivos. Rev Colomb Salud Ocup. 2016;6(2):1–8. Doi: https://doi.org/10.18041/2322-634X/rcso.2.2016.4913
Horowitz H. Fever of Unknown Origin or Fever of Too Many Origins? N Engl J Med [Internet]. 2013 [citado 8 de febrero de 2020];368(3):197–9. Recuperado a partir de: http://www.nejm.org/doi/abs/10.1056/NEJMp1212725
Young P, Saxena M, Bellomo R, Freebairn R, Bellomo R, Hammonf N, et al. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. N Engl J Med [Internet]. 2015 [citado 8 de febrero de 2020];373(23):2215–24. Recuperado a partir de: http://www.nejm.org/doi/10.1056/NEJMoa1508375
Kuwaki T. Thermoregulation under pressure: a role for orexin neurons. Temperature [Internet]. 2015 [citado 8 de febrero de 2020];2(3):379–91. Recuperado a partir de: http://www.tandfonline.com/doi/full/10.1080/23328940.2015.1066921
Zhen C, Xia Z, Ya Jun Z, Long L, Jian S, Gui-Ju C, et al. Accuracy of Infrared Tympanic Thermometry Used in the Diagnosis of Fever in Children: A Systematic Review and Meta-Analysis. Clin Pediatr (Phila) [Internet]. 2015 [citado 8 de febrero de 2020];54(2):114–26. Recuperado a partir de: http://cpj.sagepub.com/cgi/doi/10.1177/0009922814545492
Smith C, Lee-Miller C, Dishop M, Cost C, et Al. Multicentric Castleman disease presenting with fever. J Pediatr [Internet]. 2014[cited 2016 Nov 3];165(6):1261–5. Recuperado a partir de: http://www.jpeds.com/article/S0022347614007896/fulltext
Morrison S, Nakamura K, Madden C. Central control of thermogenesis in mammals. Exp Physiol [Internet]. 2008 [citado 8 de febrero de 2020];93(7):773–97. Recuperado a partir de: http://doi.wiley.com/10.1113/expphysiol.2007.041848
He Q, Johnston J, Zeitlinger J. ChIP-nexus enables improved detection of in vivo transcription factor binding footprints. Nat Biotechnol [Internet]. 2015 [citado 8 de febrero de 2020];33(4):395–401. Recuperado a partir de: http://www.nature.com/doifinder/10.1038/nbt.3121
Sánchez J, Romero C, Muñoz L, Rivera R. El órgano adiposo, un arcoiris de regulación metabólica y endocrina. Rev Cuba Endocrinol. [Internet] 2016 [citado 8 de febrero de 2020];27(1):105–19. Recuperado a partir de: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-29532016000100010
Scott H, Tyton T, Horswill C. Conducta ocupacional sedentaria y soluciones para aumentar la termogénesis no asociada al ejercicio. Rev ciencias del Ejerc y la salud. 2016;14(2):22–43. Doi:http://dx.doi.org/10.15517/pensarmov.v14i2.27496
Knobel-Dail R, Holditch-Davis D, Sloane B, Guenther D, Laurence M. Body temperature in premature infants during the first week of life: Exploration using infrared thermal imaging. Journal of Thermal Biology. 2017; 69: 118-123.
Kollmann-Camaiora A, Alsina E, Domínguez A, del-Blanco B, Yepes MJ, Guerrero JL, García. Clinical protocol for the management of malignant hyperthermia. Revista Española de Anestesiología y Reanimación. 2017; 64(1): 32-40. DOI: http://dx.doi.org/10.1016/j.redar.2016.06.004
Romanovsky A. Handbook of Clinical Neurology, Thermoregulation, From Basic Neuroscience to Clinical Neurology Part I, Volume 156. 1st ed. Oxford: Elsevier; 2018.
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