Pertinence of D-dimer request in patients in emergency services

Keywords: Pulmonary Embolism, Venous Thrombosis, Probability, Diagnostic Errors, Computed Tomography Angiography

Abstract

Introduction. Pulmonary thromboembolisms and deep vein thromboses are relatively common cardiovascular emergencies. Various clinical predictors, serial biomarkers and imaging tests have been described for the stratification of the risk. D-dimer has been described within the serial biomarkers. Since venous thromboembolic disease is a diagnostic challenge for doctors, the objective of this study was to assess the pertinence of the D-dimer request in emergency services in a level three center in Bogotá during 2018-2019. Methodology. An observational, descriptive and cross-sectional retrospective study of patients who resorted to emergency services in a level three clinic in Bogotá during 2018-2019. Results. 583 medical records were reviewed, and 107 patients were excluded, with a final total of 474 patients (57.3% women and 42.6% men). Of these, 21 patients had positive studies (angiotomography and venous doppler ultrasound). D-dimer had a negative predictive value of less than 50%. Discussion. Despite the results and it being a study in a single clinic, the difficulties emergency service doctors experience when requesting diagnostic tests can be observed.Conclusions. This study shows the difficulties in emergency services when performing a diagnosis. The request for complementary tests has to be a standardized process guided by the reasons for the consultation and findings from the physical exam, in order not to lose the operational characteristics of the diagnostic tests and their usefulness during the clinical evaluation.

Author Biographies

Santiago Sánchez-Pardo, Clínica Colsanitas, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio

Physician, Specialist in Internal Medicine, Infectology Fellow. Clínica Colsanitas, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio. Bogotá, Cundinamarca, Colombia.

Luis Carlos Rodríguez-Peralta, Clínica los Nogales

Physician, Specialist in Epidemiology. Clínica los Nogales. Bogotá, Cundinamarca, Colombia.

References

Torbicki A, Perrier A, Konstantinides S, Agnelli G, Galié N, Pruszczyk P, et al. Guías de práctica clínica de la Sociedad Europea de Cardiología. Guías de práctica clínica sobre diagnóstico y manejo del tromboembolismo pulmonar agudo. Rev Esp Cardiol [Internet]. 2008;61(12):1330.e1-1330.e52. Recuperado a partir de: https://secardiologia.es/images/stories/documentos/guia-tep.pdf

Murin S, Romano PS, White RH. Comparison of Outcomes after Hospitalization for Deep Venous Thrombosis or Pulmonary Embolism. Thromb Haemost [Internet]. 2002;88(3):407-14. doi: https://doi.org/10.1055/s-0037-1613230

Nordstrom M, Lindblad B. Autopsy-verified venous thromboembolism within a defined urban population - the city of Malmö, Sweden. APMIS [Internet]. 1998;106(3):378-84. doi: https://doi.org/10.1111/j.1699-0463.1998.tb01360.x

Oger E. Incidence of Venous Thromboembolism: A Community-based Study in Western France. EPI-GETBP Study Group. Groupe d’Etude de la Thrombose de Bretagne Occidentale. Thromb Haemost [Internet]. 2000;83(5):657-60. doi: https://doi.org/10.1055/s-0037-1613887

Dalen JE, Alpert JS. Natural history of pulmonary embolism. Prog Cardiovasc Dis [Internet]. 1975;17(4):259-70. doi: https://doi.org/10.1016/S0033-0620(75)80017-X

Sane M, Laukkanen, JA, Graner M, Piilonen A, Raade M, Harjola, VP, et al. Combined volume of pulmonary embolism and deep venous thrombosis- Association with FV, platelet count, and D-dimer. Int J Lab Hematol [Internet]. 2018;40(5):e102-e104. doi: https://doi.org/10.1111/ijlh.12867

Glober N, Tainter CR, Brennan J, Darocki M, Klingfus M, Choi M, et al. Use of the d-dimer for Detecting Pulmonary Embolism in the Emergency Department. J Emerg Med [Internet]. 2018;54(5):585–592. doi: https://doi.org/10.1016/j.jemermed.2018.01.032

Chicangana G, Zapata L, Gómez JC, Zuluaga JP. Trombólisis sistémica exitosa en un paciente con tromboembolismo pulmonar masivo, luego de reanimación cardiocerebropulmonar prolongada. Informe de caso. Rev Col Anest [Internet]. 2016;44(3):246–49. doi: https://doi.org/10.1016/j.rca.2016.02.001

Heit JA. The Epidemiology of Venous Thromboembolism in the Community. Arterioscler Thromb Vasc Biol [Internet]. 2008;28(3):370–2. doi: https://doi.org/10.1161/atvbaha.108.162545

Çil C, Çelik O, Özlek B, Özlek E, Biteker M, Yıldırım B. Prognostic value of D-dimer in patients with pulmonary embolism with and without deep vein thrombosis. Am J Emerg Med [Internet]. 2018;36(6):1099–100. doi: https://doi.org/10.1016/j.ajem.2018.02.025

Francis S, Limkakeng A, Zheng H, Hollander J, Fermann G, Parry BA, et al. Highly Elevated Quantitative D-Dimer Assay Values Increase the Likelihood of Venous Thromboembolism. TH Open [Internet]. 2019;3(1):e2-e9. doi: https://dx.doi.org/10.1055%2Fs-0038-1677029

Moumneh T, Penaloza A, Roy PM. Trombosis venosa profunda. EMC-Tratado de Medicina [Internet]. 2018;22(1):1–6. doi: https://doi.org/10.1016/S1636-5410(17)87867-3

Konstatinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Heart J [Internet]. 2020;41(4):543-603. doi: https://doi.org/10.1093/eurheartj/ehz405

van der Hulle T, Cheung WY, Kooij S, Beenen LFM, van Bemmel T, van Es J, et al. Simplified diagnostic management of suspected pulmonary embolism (the YEARS Study): a prospective, multicentre, cohort study. Lancet [Internet]. 2017;390(10091):289–97. doi: https://doi.org/10.1016/s0140-6736(17)30885-1

Wells PS, Ginsberg JS, Anderson DR, Kearon C, Gent M, Turpie AG, et al. Use of a Clinical Model for Safe Management of Patients with Suspected Pulmonary Embolism. Ann Intern Med [Internet]. 1998;129(12):997-1005. doi: https://doi.org/10.7326/0003-4819-129-12-199812150-00002

Campbell SG, Innes GD, Magee KD, Elnenaei MO, Rowe BH. A five-step program for diagnostic test addiction. CJEM [Internet]. 2019;21(5):576-9. doi: https://doi.org/10.1017/cem.2019.350

Di Nisio M, van Es N, Büller HR. Deep vein thrombosis and pulmonary embolism. Lancet [Internet]. 2016;388(10063):3060-73. doi: https://doi.org/10.1016/S0140-6736(16)30514-1

Aizman, A, Mercado M, Andresen M. Tromboembolismo pulmonar: estratificación de riesgo y dilemas terapéuticos. Rev médica Chile [Internet]. 2012;140(11):1482-9. doi: https://doi.org/10.4067/S0034-98872012001100016

Calvillo-Batllés P. Algoritmo para el diagnóstico y el seguimiento de la tromboembolia pulmonar aguda. Radiología [Internet]. 2017;59(1):75-87. doi: https://doi.org/10.1016/j.rx.2016.10.001

Jaimes F. Pruebas diagnósticas: uso e interpretación. Acta Med Colomb [Internet]. 2007;32(1):29-33. Recuperado a partir de: http://www.scielo.org.co/pdf/amc/v32n1/v32n1a7.pdf

Bianchi MT, Alexander BM. Evidence based diagnosis: does the language reflect the theory? BMJ [Internet]. 2006;333:442-5. doi: https://doi.org/10.1136/bmj.38915.558738.55

McGee S. Teaching Evidence-Based Physical Diagnosis: Six Bedside Lessons. South Med J [Internet]. 2016;109(12):738-42. doi: https://doi.org/10.14423/smj.0000000000000572

Good Stewardship Working Group. The “top 5” lists in primary care: Meeting the Responsibility of Professionalism. Arch Intern Med [Internet]. 2011;171(15):1385-90. doi: https://doi.org/10.1001/archinternmed.2011.231

Wolfson D, Santa J, Slass L. Engaging Physicians and Consumers in Conversations About Treatment Overuse and Waste: A Short History of the Choosing Wisely Campaign. Acad Med [Internet]. 2014;89(7):990-5. doi: https://doi.org/10.1097/ACM.0000000000000270

Bhandari M, Montori VM, Swiontkowski MF, Guyatt GH. User’s Guide to the Surgical Literature: How to Use an Article About a Diagnostic Test. J Bone Joint Surg Am [Internet]. 2003; 85(6):1133-40. doi: https://doi.org/10.2106/00004623-200306000-00027

van Walraven C, Naylor CD. Do We Know What Inappropriate Laboratory Utilization Is? A Systematic Review of Laboratory Clinical Audits. JAMA [Internet]. 1998;280(6):550–8. doi: https://doi.org/10.1001/jama.280.6.550

McGee S. Simplifying likelihood ratios. J Gen Intern Med [Internet]. 2002;17:647–650. doi: https://dx.doi.org/10.1046%2Fj.1525-1497.2002.10750.x

How to Cite
1.
Sánchez-Pardo S, Rodríguez-Peralta LC. Pertinence of D-dimer request in patients in emergency services . MedUNAB [Internet]. 2022 Jan. 5 [cited 2026 Mar. 9];24(3):340-6. Available from: https://revistasunabeduco.biteca.online/index.php/medunab/article/view/3958

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2022-01-05

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